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2008 Tentative Program Schedule

Thursday, October 2, 2008

7:00 PM: Arrival and Registration

Friday, October 3, 2008

7:00 - 7:50 AM - Registration and Breakfast

7:50 - 8:00 AM - Welcome and Opening - Greg Shelness, PhD, Wake Forest University

Session 1: BIOLOGY OF PEPTIDE-BASED HDL MIMETICS
Moderator: G.M. Anantharamaiah, PhD, University of Alabama, Birmingham

8:00 - 8:30 AM - Vinod K. Mishra, PhD, University of Alabama, Birmingham

  • "Determinants of Biological Activity of Apolipoprotein Mimetics"

8:30 - 9:00 AM - C. Roger White, PhD, University of Alabama, Birmingham

  • "Alternate Applications of HDL Mimetic Peptides: Protective Mechanism(s) of 4F Action in Sepsis"

9:00 - 9:30 AM - Kirkwood A. Pritchard, Jr., PhD, Medical College of Wisconsin

  • "4F, an Apo A-I Mimetic with Diverse Anti-Atherogenic and Vascular Protective Properties"

9:30 - 10:00 AM - Stephen J. Peterson, MD , New York Medical College

  • "Treatment with Apoliprotein A-1 Mimetic Peptide, L-4F, Reduces Insulin Resistance and Ameliorates Diabetes by Increasing Adiponectin and Inhibiting Interleukin 1ß in Obese Mice"

10:00 AM - 10:30 AM - BREAK

Session 2: LIPOPROTEIN METABOLSIM AND ATHEROGENESIS
Moderator: Richard B. Weinberg, MD, Wake Forest University

10:30 - 11:00 AM - Richard B. Weinberg, MD, Wake Forest University

  • "Apolipoprotein A-IV and Intestinal Lipid Absorption"

11:00 - 11:30 AM - Dennis D. Black, MD, University of Tennessee

  • "Function and Regulation of Apo A-IV in the Small Intestine"

11:30 - 12:00 PM - Rosanne Crooke, PhD, ISIS Pharamaceuticals

  • "Modulation of Lipid Metabolism by Antisense Technology"

12:00 - 12:30 PM - J. Mark Brown, PhD, Wake Forest University

  • "Inhibition of Stearoyl-CoA Desaturase 1 (SCD1) Dissociates Insulin Resistance and Obesity from Atherogenesis"

AFTERNOON FREE

Session 3: MOLECULAR MECHANISMS OF METABOLIC SYNDROME
Moderator: Sheila Collins, PhD, Hamner Institutes for Health Sciences

7:00 - 7:30 PM - Rosalind A. Coleman, MD, University of North Carolina at Chapel Hill

  • "Surprising Findings from Acyl-CoA Synthetase Knockout Mice"

7:30 - 8:00 PM - Wenhong Cao, MD, Hamner Institutes for Health Sciences

  • "Prolonged Exposure to Insulin Suppresses Mitochondrial Biogenesis"

8:00 - 8:30 PM - Jacques Robidoux, PhD, East Carolina University

  • "Epidermal Growth Factor Receptor Regulation of Adipogenesis"

8:30 - 9:00 PM Sheila Collins, PhD, Hamner Institutes for Health Sciences

  • "Beta-Adrenergic Receptor Signaling and Kinase Pathways Regulating Fat Cell Metabolism"

Saturday, October 4, 2008

7:00 - 8:00 AM - Breakfast

Session 4: THE CHANGING CONCEPTS OF TRIGLYCERIDES
Moderator: W. Virgil Brown, MD, Emory University

8:00 - 8:30 AM - Peter W. F. Wilson, MD, Emory University

  • "Post Prandial Triglycerides as a Risk Factor"

8:30 - 9:00 AM - Ngoc-Anh Le, PhD, Emory University

  • "Insulin and Post-Prandial Inflammatory Factors"

9:00 - 9:30 AM - W. Virgil Brown, MD, Emory University

  • "Fibrates: Triglyceride Reduction and Microvascular Disease"

9:30 - 10:00 AM - Andrew K. Taggart, PhD, Merck Research Laboratories

  • "Niacin: New Understanding of an Old Triglyceride Lowering Drug"

10:00 AM - 10:30 AM - BREAK

Session 5: SIGNALING AND ATHEROGENESIS
Moderator: Gabor Tigyi, MD, PhD, University of Tennessee

10:30 - 11:00 AM - Norbert Leitinger, PhD, University of Viirginia,

  • "Toll-like receptor 2 is a sensor for oxidative tissue damage: implications for atherosclerosis and diabetes"

11:00 - 11:30 AM - Gabor Tigyi, MD, PhD, University of Tennessee

  • "Lysophosphatidic Acid Regulation of Vascular Wall Remodeling"

11:30 - 12:00 PM - Kelley M. Argraves, PhD, Medical University of South Carolina

  • "Sphingosine-1-Phosphate Signaling via High Density Lipoproteins"

12:00 - 12:30 PM - Mary G. Sorci-Thomas, PhD, Wake Forest University

  • "ApoA-I and Regulation of Inflammation"

12:30 - 3:30 PM - BREAK

3:30 PM - 5:30 PM - POSTER SESSION AND COMPETITION

6:00 PM - 7:15 PM: Saturday Evening Keynote Address

Stephen G. Young, MD
David Geffen School of Medicine
University of California, Los Angeles

"Glycosylphosphatidylinositol-Anchored High-Density Lipoprotein-Binding
Protein and Lipolytic Processing of Chylomicrons"

Sunday, October 5, 2008

7:00 - 8:00 AM - Breakfast

Session 6: PATHOPHYSIOLOGY OF INCREASED CARDIOVASCULAR RISK IN TYPE 2 DIABETES.
Moderator: Marshall Elam, MD, PhD, University of Tennessee

8:00 - 8:30 AM - David A. Gordon, PhD, Bristol-Myers Squibb

  • "Inhibition of 11B-Hydroxysteroid Dehydrogenase Type 1: A Novel Approach to Treating Hyperglycemia and Hyperlipidemia"

8:30 - 9:00 AM - MacRae F. Linton, MD, Vanderbilt University

  • "Roles of Fatty Acid Binding Proteins in Atherosclerosis and Insulin Resistance"

9:00 - 9:30 AM - Lisa R. Tannock, MD, University of Kentucky

  • "Proteoglycan Mediated Lipoprotein Retention: a Mechanism of Diabetic Atherosclerosis"

9:30 - 10:00 AM - Marshall Elam, MD, PhD, University of Tennessee

  • "Hepatic Gene Expression in Morbidly Obese Humans: Insights into the Mechanisms Underlying Dyslipidemia in Obesity and Type II Diabetes"

10:00 AM - 10:30 AM - BREAK

Session 7: LIPID DROPLET BIOLOGY
Moderator: Nancy Webb, PhD, University of Kentucky

10:30 - 11:00 AM - Dawn L. Brasaemle, PhD, Rutgers University

  • "Lipid Droplet-Associated Proteins and Control of Triacylglycerol Metabolism"

11:00 - 11:30 AM - Shobha Ghosh, PhD, Virginia Commonwealth University

  • "Macrophage Cholesterol Homeostasis: Beyond Atherosclerosis"

11:30 - 12:00 PM - Nancy R. Webb, PhD, University of Kentucky

  • "Group X sPLA2 Regulates Lipolysis in Adipose Tissue"
page updated 8/28//2008